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Proteintech
PSTPIP1 Polyclonal Antibody
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Product Details
11951-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSTPIP1 Fusion Protein Ag2551 (1-350 aa encoded by BC008602)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MMPQLQFKD AFWCRDFTAH TGYEVLLQRL LDGRKMCKDM EELLRQRAQA EERYGKELVQ IARKAGGQTE INSLRASFDS LKQQMENVGS SHIQLALTLR EELRSLEEFR ERQKEQRKKY EAVMDRVQKS KLSLYKKAME SKKTYEQKCR DADDAEQAFE RISANGHQKQ VEKSQNKARQ CKDSATEAER VYRQSIAQLE KVRAEWEQEH RTTCEAFQLQ EFDRLTILRN ALWVHSNQLS MQCVKDDELY EEVRLTLEGC SIDADIDSFI QAKSTGTEPP APVPYQNYYD REVTPLTSSP GIQPSCGMIK RFSGLLHGSP KTTSLAASAA STETLTPTPE RNEGVYTAIA V (1-350 aa encoded by BC008602)
Target Information
PSTPIP1 is involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; H-PIP; PEST phosphatase-interacting protein 1; Proline-serine-threonine phosphatase-interacting protein 1; truncated proline-serine-threonine phosphatase interacting protein 1
Gene Aliases: CD2BP1; CD2BP1L; CD2BP1S; def-2; H-PIP; PAPAS; PSTPIP; PSTPIP1
UniProt ID: (Human) O43586, (Mouse) P97814
Entrez Gene ID: (Human) 9051, (Mouse) 19200, (Rat) 300732
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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