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Invitrogen
PSTPIP1 Polyclonal Antibody
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FIGURE: 1 / 3
PSTPIP1 Antibody (PA5-96793) in IHC (P)
Immunohistochemistry analysis of PSTPIP1 in paraffin-embedded human stomach. Samples were incubated with PSTPIP1 Polyclonal antibody (Product # PA5-96793) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96793
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_0039692)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AFERISANGH QKQVEKSQNK ARQCKDSATE AERVYRQSIA QLEKVRAEWE QEHRTTCEAF QLQEFDRLTI LRNALWVHSN QLSMQCVKDD ELYEEVRLTL EGCSIDADID SFIQAKSTGT EPPAPVPYQN YYDREVTPLT SSPGIQPSCG MIKRFSGLLH GSPKTTSLAA SAASTETLTP TPERNEGVYT AIAVQEIQGN PASPAQEYRA LYDYTAQNPD ELDLSAGDIL EVILEGEDGW WTVERNGQRG FVPGSYLEKL; Positive Samples: THP-1, mouse spleen, mouse thymus, mouse brain, rat brain, Mouse spleen, Mouse thymus, Mouse brain, Rat brain; Cellular Location: Cell projection, Cleavage furrow, Cytoplasm, cytoskeleton, lamellipodium, perinuclear region, uropodium
Target Information
PSTPIP1 is involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; H-PIP; PEST phosphatase-interacting protein 1; Proline-serine-threonine phosphatase-interacting protein 1; similar to Mus musculus PEST phosphatase interacting protein, encoded by GenBank Accession Number U87814; unnamed protein product
Gene Aliases: AICZC; CD2BP1; CD2BP1L; CD2BP1S; def-2; H-PIP; PAPA; PAPAS; PSTPIP; PSTPIP1
UniProt ID: (Human) O43586, (Mouse) P97814
Entrez Gene ID: (Human) 9051, (Mouse) 19200, (Rat) 300732
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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