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Proteintech
PTGER3 Polyclonal Antibody
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Product Details
14357-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTGER3 Fusion Protein Ag5711 (1-374 aa encoded by BC024229)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKETRGYGG DAPFCTRLNH SYTGMWAPER SAEARGNLTR PPGSGEDCGS VSVAFPITML LTGFVGNALA MLLVSRSYRR RESKRKKSFL LCIGWLALTD LVGQLLTTPV VIVVYLSKQR WEHIDPSGRL CTFFGLTMTV FGLSSLFIAS AMAVERALAI RAPHWYASHM KTRATRAVLL GVWLAVLAFA LLPVLGVGQY TVQWPGTWCF ISTGRGGNGT SSSHNWGNLF FASAFAFLGL LALTVTFSCN LATIKALVSR CRAKATASQS SAQWGRITTE TAIQLMGIMC VLSVCWSPLL IMMLKMIFNQ TSVEHCKTHT EKQKECNFFL IAVRLASLNQ ILDPWVYLLL RKILLRKFCQ MRKRRLREQE EFWGN (1-374 aa encoded by BC024229)
Target Information
CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EP3 prostanoid receptor EP3-III isoform; Ep3 receptor; G-protein coupled receptor; PTGER3; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2 receptor splice variant; isoform EP3-I; PGE2-R; pr; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; Prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); Prostanoid EP3 receptor; unnamed protein product
Gene Aliases: EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; EP3e; lnc003875; PGE2-R; Pgerep3; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b
UniProt ID: (Human) P43115, (Rat) P34980
Entrez Gene ID: (Human) 5733, (Rat) 24929, (Mouse) 19218
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell death
intestine smooth muscle contraction
positive regulation of fever generation
negative regulation of gastric acid secretion
fever generation
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
bicarbonate transport
response to lipopolysaccharide
positive regulation of urine volume
desensitization of G-protein coupled receptor protein signaling pathway
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
positive regulation of neutrophil extravasation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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