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Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
Assay-dependent | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PTGER3 Fusion Protein Ag5711 (1-374 aa encoded by BC024229) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.19 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MKETRGYGG DAPFCTRLNH SYTGMWAPER SAEARGNLTR PPGSGEDCGS VSVAFPITML LTGFVGNALA MLLVSRSYRR RESKRKKSFL LCIGWLALTD LVGQLLTTPV VIVVYLSKQR WEHIDPSGRL CTFFGLTMTV FGLSSLFIAS AMAVERALAI RAPHWYASHM KTRATRAVLL GVWLAVLAFA LLPVLGVGQY TVQWPGTWCF ISTGRGGNGT SSSHNWGNLF FASAFAFLGL LALTVTFSCN LATIKALVSR CRAKATASQS SAQWGRITTE TAIQLMGIMC VLSVCWSPLL IMMLKMIFNQ TSVEHCKTHT EKQKECNFFL IAVRLASLNQ ILDPWVYLLL RKILLRKFCQ MRKRRLREQE EFWGN (1-374 aa encoded by BC024229)
CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ep3 receptor; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; Prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); Prostanoid EP3 receptor
Gene Aliases: EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; EP3e; PGE2-R; Pgerep3; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b
UniProt ID: (Human) P43115, (Rat) P34980
Entrez Gene ID: (Human) 5733, (Rat) 24929, (Mouse) 19218
Molecular Function:
G-protein coupled receptor
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