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Product Details
14357-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTGER3 Fusion Protein Ag5711 (1-374 aa encoded by BC024229)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKETRGYGG DAPFCTRLNH SYTGMWAPER SAEARGNLTR PPGSGEDCGS VSVAFPITML LTGFVGNALA MLLVSRSYRR RESKRKKSFL LCIGWLALTD LVGQLLTTPV VIVVYLSKQR WEHIDPSGRL CTFFGLTMTV FGLSSLFIAS AMAVERALAI RAPHWYASHM KTRATRAVLL GVWLAVLAFA LLPVLGVGQY TVQWPGTWCF ISTGRGGNGT SSSHNWGNLF FASAFAFLGL LALTVTFSCN LATIKALVSR CRAKATASQS SAQWGRITTE TAIQLMGIMC VLSVCWSPLL IMMLKMIFNQ TSVEHCKTHT EKQKECNFFL IAVRLASLNQ ILDPWVYLLL RKILLRKFCQ MRKRRLREQE EFWGN (1-374 aa encoded by BC024229)
Target Information
CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ep3 receptor; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; Prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); Prostanoid EP3 receptor
Gene Aliases: EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; EP3e; PGE2-R; Pgerep3; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b
UniProt ID: (Human) P43115, (Rat) P34980
Entrez Gene ID: (Human) 5733, (Rat) 24929, (Mouse) 19218
inflammatory response
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
female pregnancy
cell death
positive regulation of gene expression
negative regulation of norepinephrine secretion
intestine smooth muscle contraction
urinary bladder smooth muscle contraction
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
positive regulation of fever generation
response to estradiol
response to progesterone
response to drug
positive regulation of vasoconstriction
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of insulin secretion
maternal process involved in parturition
negative regulation of gastric acid secretion
cellular response to lipopolysaccharide
cellular response to interleukin-1
negative regulation of platelet aggregation
negative regulation of potassium ion transmembrane transport
response to salt
negative regulation of calcium ion transmembrane transport
negative regulation of gastrin-induced gastric acid secretion
positive regulation of smooth muscle contraction involved in micturition
cellular response to forskolin
positive regulation of inhibitory G-protein coupled receptor phosphorylation
negative regulation of circadian sleep/wake cycle, wakefulness
positive regulation of myofibroblast contraction
positive regulation of colon smooth muscle contraction
positive regulation of gastric mucosal blood circulation
prostaglandin receptor internalization
positive regulation of neutrophil extravasation
negative regulation of forebrain neuron differentiation
fever generation
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
bicarbonate transport
response to lipopolysaccharide
positive regulation of urine volume
desensitization of G-protein coupled receptor protein signaling pathway
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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