Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Bovine, Horse, Pig (100%) Gorilla, Rat, Elephant, Bat, Rabbit (94%).
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.
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Protein Aliases: EP3; Ep3 prostanoid receptor; Ep3 receptor; EP3 subtype; Ep3 subtype pge2 receptor; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE receptor; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; Pge2 receptor ep3; PGE2 receptor EP3 subtype; PGE2-R; prostaglandin E receotor EP3 subtype 3 isoform; Prostaglandin E receptor 3; prostaglandin E receptor 3 (subtype EP3); Prostaglandin E receptor EP3; Prostaglandin e2 receptor ep3; Prostaglandin E2 receptor EP3 subtype; Prostaglandin ep3 receptor; Prostaglandin receptor (PGE-2); Prostanoid EP3 receptor; PTGER3
Gene Aliases: EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; EP3e; PGE2-R; PTGER3
UniProt ID: (Human) P43115
Entrez Gene ID: (Human) 5733