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Bethyl Laboratories
PTK7 Polyclonal Antibody
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FIGURE: 1 / 2
PTK7 Antibody (A304-452A) in WB
Detection of human and mouse PTK7 by western blot. Samples: Whole cell lysate (50 µg) prepared using NETN buffer from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells. Antibodies: Affinity purified rabbit anti-PTK7 antibody (Product # A304-452A) (lot A304-452A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A304-452A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 750 to 800 of Human Protein Tyrosine Kinase 7.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
CCK4 may function as a cell adhesion molecule. Although it belongs to the insulin receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK7 protein tyrosine kinase 7; receptor tyrosine kinase-like protein; Tyrosine-protein kinase-like 7
Gene Aliases: 8430404F20Rik; CCK-4; CCK4; chz; mPTK7/CCK4; PTK7
UniProt ID: (Human) Q13308, (Mouse) Q8BKG3
Entrez Gene ID: (Human) 5754, (Mouse) 71461
protein kinase activity
protein binding
ATP binding
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
establishment of planar polarity
ventricular septum development
axis elongation
protein phosphorylation
cell adhesion
signal transduction
positive regulation of neuron projection development
cell migration
actin cytoskeleton reorganization
wound healing
establishment of epithelial cell apical/basal polarity
convergent extension
canonical Wnt signaling pathway
lung-associated mesenchyme development
coronary vasculature development
cellular response to retinoic acid
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
neural tube closure
Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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