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PTPH1 Polyclonal Antibody
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Product Details
BS-9187R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PTPH1/PTPN3, amino acids 1-47.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation - it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytoskeletal-associated protein tyrosine phosphatase; Protein-tyrosine phosphatase H1; PTP-H1; Tyrosine-protein phosphatase non-receptor type 3; unnamed protein product
Gene Aliases: 9530011I20Rik; PTP-H1; PTPCL; PTPH1; PTPN3
UniProt ID: (Human) P26045, (Mouse) A2ALK8
Entrez Gene ID: (Human) 5774, (Rat) 362524, (Mouse) 545622
MAPK cascade
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of mitotic cell cycle
negative regulation of membrane protein ectodomain proteolysis
regulation of membrane depolarization during action potential
regulation of sodium ion transmembrane transport
protein dephosphorylation
peptidyl-tyrosine dephosphorylation
liver regeneration
regulation of sodium ion transmembrane transporter activity
dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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