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Bethyl Laboratories

PTPN2/TCPTP Polyclonal Antibody

View all (17) PTPN2 antibodies

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PTPN2/TCPTP Polyclonal Antibody

Product Details

A305-185A

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 350 to 400 of Human Tyrosine-protein phosphatase non-receptor type 2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

phosphate/tris citrate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Target Information

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PTPN 2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC PTP; TCPTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2; unnamed protein product

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Gene Aliases: PTN2; PTPN2; PTPT; TC-PTP; TC45; TC48; TCELLPTP; TCPTP

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UniProt ID: (Human) P17706

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Entrez Gene ID: (Human) 5771

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Function(s)
phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity integrin binding protein binding hydrolase activity protein kinase binding syntaxin binding receptor tyrosine kinase binding STAT family protein binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage B cell differentiation T cell differentiation erythrocyte differentiation peptidyl-tyrosine dephosphorylation insulin receptor recycling negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of STAT protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of JAK-STAT cascade negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of hepatocyte growth factor receptor signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway
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