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Proteintech
PTPRK Polyclonal Antibody
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Product Details
28151-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTPRK Fusion Protein Ag27765
Conjugate
Form
Liquid
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTP alpha, PTP beta, PTP gamma, PTP delta, PTP epsilon, PTP zeta, PTPk and PTP-mu. Transmembrane PTPs play diverse roles during development and in adult tissues. Immunodepletion studies have suggested LAR to be a regulator of Insulin receptor phosphorylation. PTP alpha activity is increased twofold in response to phorbol ester stimulation, resulting in serine phosphorylation either directly or indirectly by members of the PKC family. Overexpression of v-H-ras and Neu, but not Myc or Int2, in mammary tumors has been shown to induce PTP epsilon expression. An alternative splicing event leads to a nervous tissue-specific chondroitin sulfate proteoglycan called phosphacan, which represents the amino terminal portion of PTP zeta. PTPk and PTP-mu share a conserved amino terminal 160 amino acid MAM domain which facilitates homophilic binding. PTP-mu localizes to points of cell contact and may be involved in regulating the assembly and disassembly of cadherin/catenin complexes in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa; protein tyrosine phosphatase, receptor type, K; protein tyrosine phosphatase, receptor type, K, extracellular region; Protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase, receptor type, kappa; R-PTP-k; R-PTP-kappa; R-PTPk; receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK); Receptor-type tyrosine-protein phosphatase kappa
Gene Aliases: AI853699; PTPK; PTPRK; R-PTP-kappa; Rptpk; RPTPkappa
UniProt ID: (Human) Q15262, (Mouse) P35822
Entrez Gene ID: (Human) 5796, (Mouse) 19272, (Rat) 360302
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
protein binding
beta-catenin binding
protein kinase binding
gamma-catenin binding
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
extracellular matrix glycoprotein
protein phosphatase
protein modifying enzyme
protein dephosphorylation
cell adhesion
signal transduction
transforming growth factor beta receptor signaling pathway
negative regulation of cell proliferation
negative regulation of keratinocyte proliferation
cell migration
negative regulation of cell migration
neuron projection development
protein localization to cell surface
cellular response to reactive oxygen species
cellular response to UV
peptidyl-tyrosine dephosphorylation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
focal adhesion assembly
dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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