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Proteintech
PTRF Polyclonal Antibody
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Product Details
18892-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTRF Fusion Protein Ag13486 (1-198 aa encoded by BC008849)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEDAAALEL SSDEAVEVEE VIEESRAERI KRSGLRRVDD FKKAFSKEKM EKTKVRTREN LEKTRLKTKE NLEKTRHTLE KRMNKLGTRL VPAERREKLK TSRDKLRKSF TPDHVVYARS KTAVYKVPPF TFHVKKIREG QVEVLKATEM VEVGADDDEG GAERGEAGDL RRGSSPDVHA LLEITEESDA VLVDKSDSD (1-198 aa encoded by BC008849 )
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cav-p60; Caveolae-associated protein 1; cavin; Cavin-1; FLJ90031; Polymerase I and transcript release factor; PTRF; ptrf {ECO:0000312|RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
Gene Aliases: 2310075E07Rik; AW546441; Cav-p60; CAVIN; cavin-1; CAVIN1; CGL4; FKSG13; PTRF
UniProt ID: (Human) Q6NZI2, (Mouse) O54724
Entrez Gene ID: (Human) 284119, (Rat) 287710, (Mouse) 19285
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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