FIGURE: 1 / 4
Immunogen sequence: CLRKGGFGPR DADSDENDKG EKKNKGTFDG DKLGDLKEEG DVMDKTNGLP VQNGIDADVK DFSRTPGNCQ NSANEVDLLG PN
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 98%.
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), and 5'-UGUANAUA-3' that is related to the Nanos Response Element (NRE). PUM1 mediates post-transcriptonal repression of transcripts via different mechanisms - acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Mutations to the gene can result in spinocerebellar ataxia 47.
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Protein Aliases: HsPUM; pumilio 1; Pumilio homolog 1; pumilio RNA-binding family member 1; pumilio-1
Gene Aliases: AA517475; HSPUM; KIAA0099; mKIAA0099; PUM1; PUMH; PUMH1; PUML1; Pumm