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The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients.
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Protein Aliases: A1m {ECO:0000312|EMBL:AAA40723.1}; Alpha-1-M; Alpha-1-macroglobulin; Alpha-1-macroglobulin 165 kDa subunit
Gene Aliases: A1m; Pzp
UniProt ID: (Rat) Q63041
Entrez Gene ID: (Rat) 252922
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