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Invitrogen

Pan Ras Polyclonal Antibody

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Pan Ras Polyclonal Antibody

Product Details

PA5-78035

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Amphibian, Goat, Human, Mouse, Rodent, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human KRAS. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Amount

27 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736317

Product Specific Information

Positive Control: A549, H1299, HCT116, KRAS, HRAS, NRAS, zebrafish liver, zebrafish GI, whole zebrafish

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras proto-oncogene; cellular c-Ki-ras2; GTPase HRas; GTPase Hras1; GTPase KRas; GTPase NRas; H-ras 1 protein; H-Ras-1; Ha-Ras; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene 1; K RAS; K-Ras 2; Ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene homologue 2 (active); N-ras oncogene p21; Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; p21 protein; p21ras; ras-like protein; RASK; RASN; Transforming protein N-Ras; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog a; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; xRAS1

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Gene Aliases: AI929937; AV095280; c-H-ras; c-Ha-ras; c-Ki-ras; c-rasHa; etID18709.8; fa04e08; fc14b12; fc23g10; fj89d12; fj99a10; H-ras; Ha-ras; Harvey-ras; HRAS; Hras-1; HRAS1; K-ras; Ki-ras; KRAS; Kras-2; KRAS2; N-ras; NRAS; p21; p21B; ras; RASK2; sb:eu826; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; wu:fj99a10; xRAS2; zgc:100761; zgc:110250; zgc:85725; zras-b1

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UniProt ID: (Mouse) Q61411, (Rat) P20171, (Rat) P08644, (Mouse) P32883, (Rat) Q04970

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Entrez Gene ID: (Goat) 102186668, (Mouse) 15461, (Rat) 293621, (Goat) 102172519, (Rat) 24525, (Mouse) 16653, (Goat) 102187180, (Mouse) 18176, (Rat) 24605, (Zebrafish) 550286, (Zebrafish) 445289, (Zebrafish) 30380

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Function(s)
nucleotide binding protein binding GTP binding protein C-terminus binding GTPase activity GMP binding GDP binding LRR domain binding protein complex binding molecular_function small GTPase
Process(es)
positive regulation of protein phosphorylation endocytosis apoptotic process cell cycle arrest mitotic cell cycle checkpoint signal transduction small GTPase mediated signal transduction Ras protein signal transduction cell aging cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of cell migration negative regulation of GTPase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction regulation of long-term neuronal synaptic plasticity positive regulation of epithelial cell proliferation protein heterooligomerization positive regulation of ERK1 and ERK2 cascade positive regulation of wound healing cellular senescence intrinsic apoptotic signaling pathway positive regulation of ruffle assembly positive regulation of actin cytoskeleton reorganization positive regulation of miRNA metabolic process visual learning actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction social behavior negative regulation of cell differentiation striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis cytokine-mediated signaling pathway homeostasis of number of cells within a tissue positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity response to glucocorticoid response to mineralocorticoid regulation of protein phosphorylation regulation of gene expression positive regulation of fibroblast proliferation negative regulation of skeletal muscle tissue development regulation of cell cycle establishment of protein localization to Golgi biological_process heart development hemopoiesis embryonic cranial skeleton morphogenesis
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