Positive Control: A549, H1299, HCT116, KRAS, HRAS, NRAS, zebrafish liver, zebrafish GI, whole zebrafish
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Pan RAS encodes a protein that belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-H-ras; c-has/bas p21 protein; c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-ras-Ki-2 activated oncogene; cellular c-Ki-ras2 proto-oncogene; GTP- and GDP-binding peptide B; GTPase HRas; GTPase HRas, N-terminally processed; GTPase KRas; GTPase KRas, N-terminally processed; GTPase NRas; H-Ras-1; Ha-Ras; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); N-ras oncogene p21; N-ras protein part 4; neuroblastoma RAS viral (v-ras) oncogene homolog; oncogene KRAS2; p19 H-RasIDX protein; p21ras; PR310 c-K-ras oncogene; Ras family small GTP binding protein H-Ras; ras-like protein; transformation gene: oncogene HAMSV; Transforming protein N-Ras; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog; xRAS1
Gene Aliases: ALPS4; C-BAS/HAS; C-H-RAS; C-HA-RAS1; C-K-RAS; c-Ki-ras; CFC2; CMNS; CTLO; etID18709.8; fa04e08; fc14b12; fc23g10; fj89d12; fj99a10; H-RASIDX; HAMSV; HRAS; HRAS1; K-ras; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; KRAS1; KRAS2; N-ras; NCMS; NRAS; NRAS1; NS; NS3; NS6; p21; p21ras; RALD; RASH1; RASK2; sb:eu826; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; wu:fj99a10; xRAS2; zgc:100761; zgc:110250; zgc:85725; zras-b1