Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Pan Ras Polyclonal Antibody

Advanced Verification
View all (17) Pan Ras antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Pan Ras Polyclonal Antibody

Product Details

PA5-78035

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Amphibian, Goat, Human, Mouse, Rodent, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human KRAS. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Amount

27 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736317

Product Specific Information

Positive Control: A549, H1299, HCT116, KRAS, HRAS, NRAS, zebrafish liver, zebrafish GI, whole zebrafish

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: c-Ha-ras p21 protein; c-Ha-ras transgene; c-has/bas p21 protein; c-K-ras; c-K-ras2 protein; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-ras-Ki-2 protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; GTP- and GDP-binding peptide B; GTPase Hras1; H-ras 1 protein; H-Ras-1; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene; Harvey rat sarcoma virus oncogene 1; HRAS; K RAS; K-Ras 2; K-ras p21 protein; ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kirsten rat sarcoma viral proto-oncogene; KRAS-ENOPH fusion; Kras-Enoph1 fusion protein; N-ras oncogene p21; N-ras protein part 4; Neuroblastoma RAS; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; Nras; oncogene KRAS2; p19 H-RasIDX protein; p21 protein; p21ras; PR310 c-K-ras oncogene; PR371 c-K-ras oncogene; proto-oncogene GTPase; Ras family small GTP binding protein H-Ras; ras-like protein; RASK; RASN; small GTP binding protein; transformation gene: oncogene HAMSV; transforming protein N-Ras; transforming protein P21; unnamed protein product; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ha-ras Harvey rat sarcoma viral oncogene homolog a; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog; xRAS1

View more View less

Gene Aliases: 'C-K-RAS; ALPS4; C-BAS/HAS; C-H-RAS; c-Ha-ras; C-HA-RAS1; C-K-RAS; c-Ki-ras; c-Ki-ras2; c-rasHa; CFC2; CMNS; CTLO; etID18709.8; fa04e08; fc14b12; fc23g10; fj89d12; fj99a10; H-ras; H-RASIDX; Ha-ras; HAMSV; Harvey-ras; hras; Hras-1; HRAS1; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; Kras-2; KRAS1; KRAS2; N-ras; NCMS; NRAS1; NS; NS3; NS6; OES; p21; p21B; p21ras; RALD; RALD1; RALD2; ras; RASH1; RASK2; sb:eu826; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; wu:fj99a10; xRAS2; zgc:100761; zgc:110250; zgc:85725; zras-b1

View more View less

UniProt ID: (Human) P01112, (Mouse) Q61411, (Rat) P20171, (Human) P01116, (Rat) P08644, (Mouse) P32883, (Human) P01111, (Rat) Q04970

View more View less

Entrez Gene ID: (Goat) 102186668, (Human) 3265, (Mouse) 15461, (Rat) 293621, (Human) 3845, (Goat) 102172519, (Rat) 24525, (Mouse) 16653, (Goat) 102187180, (Human) 4893, (Mouse) 18176, (Rat) 24605, (Zebrafish) 550286, (Zebrafish) 445289, (Zebrafish) 30380

View more View less

Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding GDP binding protein anchor phospholipase C activator activity macromolecular complex binding GMP binding LRR domain binding identical protein binding nucleotide binding small GTPase
Process(es)
MAPK cascade regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway Ras protein signal transduction positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis negative regulation of gene expression Schwann cell development positive regulation of cell migration regulation of actin cytoskeleton organization regulation of cell proliferation myelination positive regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction positive regulation of epithelial cell proliferation regulation of cell cycle adipose tissue development positive regulation of ERK1 and ERK2 cascade cellular response to gamma radiation positive regulation of wound healing positive regulation of protein targeting to membrane cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of ruffle assembly positive regulation of miRNA metabolic process endocytosis small GTPase mediated signal transduction positive regulation of gene expression positive regulation of interferon-gamma production ERBB2-ERBB3 signaling pathway T-helper 1 type immune response defense response to protozoan negative regulation of neuron apoptotic process insulin-like growth factor receptor signaling pathway regulation of long-term neuronal synaptic plasticity T cell receptor signaling pathway oncogene-induced cell senescence intrinsic apoptotic signaling pathway liver development response to isolation stress positive regulation of DNA replication I-kappaB kinase/NF-kappaB signaling female pregnancy response to gravity cytokine-mediated signaling pathway positive regulation of TOR signaling negative regulation of programmed cell death response to glucocorticoid response to mineralocorticoid myoblast proliferation cardiac muscle cell proliferation positive regulation of cellular senescence visual learning gene expression forebrain astrocyte development actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction positive regulation of MAP kinase activity negative regulation of cell differentiation homeostasis of number of cells within a tissue positive regulation of nitric-oxide synthase activity striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis positive regulation of endothelial cell proliferation regulation of protein phosphorylation regulation of gene expression positive regulation of angiogenesis positive regulation of fibroblast proliferation negative regulation of skeletal muscle tissue development myoblast differentiation heart development hemopoiesis embryonic cranial skeleton morphogenesis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support