This peptide antibody is broadly cross-reactive with all members of the cadherin family of proteins including N-cadherin, E-cadherin, P-cadherin, and R-cadherin. The antibody also displays broad species cross-reactivity including human, bovine, mouse, rat, chicken, amphibian, as well as other species. Rabbit anti-pan-Cadherin is useful as both a ubiquitous cadherin probe as well as a marker for adherens junctions.
71-7100 was used successfully in the immunofluorescence analysis of pan cadherin in MDCK cells.
Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
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Protein Aliases: ARC-1; ATP-dependent helicase CHD1; ATP-dependent helicase CHD3; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 15, M-cadherin (myotubule); cadherin 2; cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; CHD-1; CHD-3; Chromodomain-helicase-DNA-binding protein 1; Chromodomain-helicase-DNA-binding protein 3; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-Cadherin; E-cadherin 1; Epithelial cadherin; hZFH; L-CAM; Liver cell adhesion molecule; liver cell adhesion protein; Maternally-expressed neural cadherin; Mi-2 alpha; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; N-cadherin; N-cadherin 1; Neural cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; Uvomorulin; XmN-cadherin; xTCAD-1; Zinc finger helicase; zinc-finger helicase (Snf2-like)
Gene Aliases: 2600010P09Rik; 4930525N21Rik; AA960649; AF020312; AI385538; AI851787; Arc-1; AW120700; AW555109; CAD4; Cadherin-1; Cadp; CD324; CD325; CDH1; CDH15; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; Chd-1; CHD1; CHD3; Chd7; E-cad; ECAD; HJMD; K-CAM; L-CAM; LCAM; Mi-2a; Mi2-ALPHA; N-cadherin; NCAD; P-cadherin; PCAD; Prp7; Prp9-1; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO; Uvomorulin; XELAEV_18024918mg; XELAEV_18046239mg; ZFH
UniProt ID: (Chicken) P08641, (Dog) F1PAA9, (Human) P12830, (Chicken) P10288, (Human) P19022, (Human) P22223, (Chicken) P24503, (Human) P55283, (Human) O14646, (Human) Q12873, (Rat) Q9R0T4, (Mouse) P09803, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038, (Mouse) P40201, (Xenopus) P79883, (Xenopus) P30944
Entrez Gene ID: (Chicken) 415860, (Dog) 442858, (Human) 999, (Dog) 480169, (Chicken) 414745, (Human) 1000, (Dog) 611010, (Human) 1001, (Chicken) 414845, (Chicken) 419222, (Dog) 100685099, (Human) 1002, (Human) 1105, (Dog) 488891, (Human) 1107, (Dog) 479489, (Rat) 83502, (Mouse) 12550, (Mouse) 12558, (Rat) 83501, (Rat) 116777, (Mouse) 12560, (Mouse) 12561, (Rat) 114588, (Mouse) 12648, (Rat) 308215, (Rat) 303241, (Mouse) 216848, (Xenopus) 108702627, (Xenopus) 100337618