This peptide antibody is broadly cross-reactive with all members of the cadherin family of proteins including N-cadherin, E-cadherin, P-cadherin, and R-cadherin. The antibody also displays broad species cross-reactivity including human, bovine, mouse, rat, chicken, amphibian, as well as other species. Rabbit anti-pan-Cadherin is useful as both a ubiquitous cadherin probe as well as a marker for adherens junctions.
71-7100 was used successfully in the immunofluorescence analysis of pan cadherin in MDCK cells.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 15, M-cadherin (myotubule); cadherin 2; cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; calcium-dependent adhesion protein; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDHE; CDHN; CDw325; CDw325 antigen; cell-CAM 120/80; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-Cadherin; E-cadherin 1; E-cadherin epithelial; ECAD; epithelial; Epithelial cadherin; L-CAM; LCAM; Liver cell adhesion molecule; liver cell adhesion protein; N-cadherin; N-cadherin 1; NCAD; Neural cadherin; P-cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; UVO; Uvomorulin; xTCAD-1
Gene Aliases: AA960649; AI385538; Arc-1; AW120700; CAD4; Cadherin-1; Cadp; CD324; CD325; CDH1; CDH15; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; E-cad; ECAD; HJMD; K-CAM; L-CAM; LCAM; N-cadherin; NCAD; P-cadherin; PCAD; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO; Uvomorulin; XELAEV_18024918mg
UniProt ID: (Chicken) P08641, (Dog) F1PAA9, (Human) P12830, (Chicken) P10288, (Human) P19022, (Human) P22223, (Chicken) P24503, (Human) P55283, (Mouse) P09803, (Rat) Q9R0T4, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038, (Xenopus) P30944
Entrez Gene ID: (Chicken) 415860, (Dog) 442858, (Human) 999, (Dog) 480169, (Chicken) 414745, (Human) 1000, (Dog) 611010, (Human) 1001, (Chicken) 414845, (Chicken) 419222, (Dog) 100685099, (Human) 1002, (Mouse) 12550, (Rat) 83502, (Mouse) 12558, (Rat) 83501, (Rat) 116777, (Mouse) 12560, (Mouse) 12561, (Rat) 114588, (Xenopus) 100337618
Molecular Function: cadherin