PA1-751 detects recombinant human parkin.
PA1-751 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects an ~52 kDa protein representing recombinant human parkin.
The PA1-751 immunizing peptide corresponds to amino acid residues 298-313 from human parkin. This sequence is completely conserved between human, mouse and rat. PA1-751 immunizing peptide (Cat. # PEP-159) is available for use in neutralization and control experiments.
The precise function of Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase parkin; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; Parkin; parkin 2; Parkin isoform 1; Parkin RBR E3 ubiquitin-protein ligase; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Gene Aliases: AR-JP; LPRS2; Park; PARK2; PDJ; PRKN
Molecular Function: ubiquitin-protein ligase