Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This antibody detects endogenous protein at a molecular weight of 42 kDa.
Purity is >95% by SDS-PAGE.
Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Pepsin A is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. Pepsin A is inhibited by ovUS-1, a uterine serpin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: pepsin A; Pepsin A-3; Pepsin A-4; Pepsin A-5; Pepsin F; pepsinogen 5, group I; pepsinogen 5, group I (pepsinogen A); pepsinogen A3; pepsinogen A4; pepsinogen A5; pepsinogen F; pepsinogen F protein; Pepsinogen-3; Pepsinogen-4; Pepsinogen-5
Gene Aliases: 1110035E17Rik; Pepf; Pg5; PGA3; PGA4; PGA5
UniProt ID: (Human) P0DJD8, (Human) P0DJD7, (Human) P0DJD9, (Mouse) Q9D106
Entrez Gene ID: (Human) 643834, (Human) 643847, (Human) 5222, (Mouse) 58803, (Rat) 60372
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