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Phospho-DAB2 (Ser24) Polyclonal Antibody

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Phospho-DAB2 (Ser24) Polyclonal Antibody

Product Details

BS-11044R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human DAB2 around the phosphorylation site of Ser24 [AP (p-S)KK].
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adaptor molecule disabled-2; C9; Dab, mitogen-responsive phosphoprotein, homolog 2; DAB2, clathrin adaptor protein; Differentially expressed in ovarian carcinoma 2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2 mitogen-responsive phosphoprotein; disabled homolog 2, mitogen-responsive phosphoprotein; DOC-2; DOC-2 p82 isoform; FLJ26626; mitogen responsive phosphoprotein; Mitogen-responsive phosphoprotein; unnamed protein product

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Gene Aliases: 5730435J12Rik; AA960054; AI957090; D15Wsu122e; D630005B22Rik; DAB2; DOC-2; DOC2; p96

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UniProt ID: (Human) P98082, (Mouse) P98078, (Rat) O88797

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Entrez Gene ID: (Human) 1601, (Mouse) 13132, (Rat) 79128

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Function(s)
protein binding clathrin adaptor activity cargo receptor activity SMAD binding low-density lipoprotein particle receptor binding integrin binding phosphatidylinositol-4,5-bisphosphate binding protein C-terminus binding clathrin binding phosphatidylinositol binding AP-2 adaptor complex binding scaffold/adaptor protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter endocytosis receptor-mediated endocytosis apoptotic process transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway positive regulation of epithelial to mesenchymal transition negative regulation of neuron projection development protein transport Wnt signaling pathway cell differentiation negative regulation of cell growth positive regulation of cell migration positive regulation of aldosterone biosynthetic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process leading edge cell differentiation negative regulation of apoptotic process positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter clathrin coat assembly response to steroid hormone negative regulation of epithelial cell proliferation positive regulation of SMAD protein import into nucleus negative regulation of androgen receptor signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus negative regulation of canonical Wnt signaling pathway positive regulation of substrate adhesion-dependent cell spreading response to salt negative regulation of protein localization to plasma membrane positive regulation of Wnt signaling pathway, planar cell polarity pathway positive regulation of clathrin-mediated endocytosis positive regulation of early endosome to late endosome transport positive regulation of aldosterone secretion cell morphogenesis involved in differentiation in utero embryonic development positive regulation of receptor recycling positive regulation of protein phosphorylation transport pinocytosis activation of JUN kinase activity multicellular organism development endoderm development excretion positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein binding positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of Rho-dependent protein serine/threonine kinase activity positive regulation of integrin-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway myeloid cell differentiation
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