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Invitrogen

Phospho-RAD50 (Ser635) Polyclonal Antibody

View all (22) RAD50 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-118714

Applications Tested Dilution Publications

Western Blot (WB)

 1:1,000-1:3,000 -

Immunohistochemistry (Paraffin) (IHC (P))

 1:50-1:200 -
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

A synthesized peptide derived from human RAD50 around the phosphorylation site of Ser635.
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Antigen affinity chromatography

Storage buffer

 PBS, pH 7.4, with 50% glycerol

Contains

 0.02% sodium azide

Storage conditions

 -20°C

RRID

AB_2903214

Target Information

Rad50-13B3 recognizes human Rad50, a 153a protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, Rad50 and Mre11 redistribute and are co-localized within the nucleus of damaged cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA repair protein RAD50; hRAD50; hsRAD50; mRad50; RAD50 2; RAD50 homolog, double strand break repair protein; RAD50 PEN; RAD50-2; RAD50-3

Gene Aliases: hRad50; Mrell; NBSLD; RAD50; RAD502; Rad50l

UniProt ID: (Human) Q92878, (Rat) Q9JIL8

Entrez Gene ID: (Human) 10111, (Mouse) 19360, (Rat) 64012

Function(s)
regulation of mitotic recombination telomere maintenance DNA repair double-strand break repair DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase cell cycle regulation of mitotic cell cycle positive regulation of protein autophosphorylation DNA duplex unwinding positive regulation of kinase activity negative regulation of viral entry into host cell chromosome organization protein heterooligomerization meiotic cell cycle chromosome organization involved in meiotic cell cycle nucleic acid phosphodiester bond hydrolysis DNA catabolic process, endonucleolytic reciprocal meiotic recombination telomere maintenance via recombination double-strand break repair via homologous recombination DNA double-strand break processing DNA synthesis involved in DNA repair strand displacement DNA replication double-strand break repair via nonhomologous end joining viral process telomeric 3' overhang formation positive regulation of telomere maintenance nucleotide phosphorylation regulation of signal transduction by p53 class mediator negative regulation of telomere capping
Process(es)
single-stranded DNA endodeoxyribonuclease activity DNA binding double-stranded telomeric DNA binding ATP-dependent DNA helicase activity adenylate kinase activity protein binding ATP binding 3'-5' exonuclease activity protein binding, bridging single-stranded telomeric DNA binding metal ion binding G-quadruplex DNA binding nucleotide binding double-stranded DNA binding hydrolase activity ATPase activity
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