Search

  • Contact Us
  • Quick Order

Invitrogen

Phospho-RARA (Ser77) Polyclonal Antibody

View all (23) RARA antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-RARA (Ser77) Polyclonal Antibody

Product Details

PA5-40165

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of serine 77 (P-P-S(p)-P-P) derived from Human Retinoic Acid Receptor alpha.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609530

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

Target Information

RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: nuclear receptor; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; PML gene product; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR Alpha; RAR alpha 1; RAR-alpha; RARA; retinoic acid; retinoic acid receptor; retinoic acid receptor, alpha polypeptide; RRA; TTMV/RARA fusion; TTMV/RARA fusion protein; unnamed protein product

View more View less

Gene Aliases: NR1B1; RAR; RARalpha; RARalpha1

View more View less

UniProt ID: (Human) P10276, (Mouse) P11416

View more View less

Entrez Gene ID: (Human) 5914, (Rat) 24705, (Mouse) 19401

View more View less

Function(s)
translation repressor activity, nucleic acid binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription coactivator binding retinoic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding protein binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding sequence-specific DNA binding retinoic acid-responsive element binding mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding heterocyclic compound binding sequence-specific double-stranded DNA binding phosphatidylinositol 3-kinase regulator activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter liver development regulation of transcription, DNA-templated protein phosphorylation germ cell development female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation male gonad development positive regulation of gene expression negative regulation of translation hippocampus development cell differentiation prostate gland development negative regulation of granulocyte differentiation regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine mRNA transcription from RNA polymerase II promoter regulation of apoptotic process apoptotic cell clearance response to ethanol positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity retinoic acid receptor signaling pathway positive regulation of binding Sertoli cell fate commitment cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus negative regulation of pri-miRNA transcription from RNA polymerase II promoter ureteric bud development neural tube closure glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development spermatogenesis negative regulation of gene expression regulation of granulocyte differentiation embryonic camera-type eye development multicellular organism growth camera-type eye development negative regulation of apoptotic process negative regulation of cell differentiation negative regulation of translational initiation embryonic organ development embryonic morphogenesis ventricular cardiac muscle cell differentiation limb development face development bone development trachea cartilage development chondroblast differentiation negative regulation of cartilage development positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support