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Invitrogen
Phospho-RASGRF1 (Ser916) Polyclonal Antibody
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Product Details
PA5-37790
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of Serine 916(N-E-G(p)-T P) derived from Human Ras-GRF1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for IHC is human brain tissue.
Target Information
RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. Studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASPP1; CDC25; CDC25 homolog; CDC25 like; CDC25Mm; GNRP; guanine nucleotide exchange factor; guanine nucleotide-releasing factor 1; guanine nucleotide-releasing factor, 55 kD; Guanine nucleotide-releasing protein; KIAA0771; P140 RAS-GRF; PPP1R13B; Ras guanine release factor beta; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific guanine nucleotide-releasing factor, CDC25 homolog; Ras-specific nucleotide exchange factor CDC25; unnamed protein product
Gene Aliases: AI844718; CDC25; CDC25L; CDC25Mm; GNRP; GRF1; GRF55; Grfbeta; H-GRF55; p190; P190-A; p190RhoGEF; PP13187; Ras-GRF1; RASGRF1
UniProt ID: (Human) Q13972, (Mouse) P27671, (Rat) P28818
Entrez Gene ID: (Human) 5923, (Mouse) 19417, (Rat) 192213
signal transduction
small GTPase mediated signal transduction
Ras protein signal transduction
long-term memory
neuron projection development
response to endoplasmic reticulum stress
positive regulation of Rac protein signal transduction
intracellular signal transduction
negative regulation of MAPK cascade
positive regulation of MAPK cascade
type B pancreatic cell proliferation
regulation of Ras protein signal transduction
positive regulation of Ras protein signal transduction
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
cell proliferation
regulation of Rac protein signal transduction
regulation of Rho protein signal transduction
positive regulation of GTPase activity
activation of GTPase activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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