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Invitrogen

Phospho-ROCK2 (Ser1366) Polyclonal Antibody

View all (38) ROCK2 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-105417

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ROCK2 around the phosphorylation site of Ser1366.
View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

RRID

AB_2816845

Target Information

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: p150 ROK-alpha; p164 ROCK-2; Rho kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); RhoA-binding kinase 2; ROCK II; ROCK-II; rockii; ROKalpha

Gene Aliases: B230113H15Rik; KIAA0619; mKIAA0619; Rho-kinase; ROCK-II; ROCK2; Rock2m; ROK; ROKalpha

UniProt ID: (Human) O75116, (Rat) Q62868, (Mouse) P70336

Entrez Gene ID: (Human) 9475, (Rat) 25537, (Mouse) 19878

Molecular Function: non-receptor serine/threonine protein kinase

Function(s)
cytokinesis positive regulation of protein phosphorylation protein phosphorylation smooth muscle contraction I-kappaB kinase/NF-kappaB signaling Rho protein signal transduction positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of centrosome duplication negative regulation of angiogenesis regulation of cell adhesion cortical actin cytoskeleton organization regulation of actin cytoskeleton organization negative regulation of myosin-light-chain-phosphatase activity regulation of circadian rhythm regulation of keratinocyte differentiation vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway rhythmic process centrosome duplication regulation of stress fiber assembly regulation of focal adhesion assembly cellular response to testosterone stimulus establishment of protein localization to plasma membrane regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly regulation of establishment of cell polarity regulation of cell motility neural tube closure extrinsic apoptotic signaling pathway via death domain receptors actin cytoskeleton organization chromosome condensation dendrite morphogenesis phosphorylation intracellular signal transduction
Process(es)
protein serine/threonine kinase activity structural molecule activity protein binding ATP binding Rho GTPase binding poly(A) RNA binding metal ion binding Rho-dependent protein serine/threonine kinase activity kinase activity nucleotide binding protein kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
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