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Invitrogen

Phospho-RUNX2 (Ser340) Polyclonal Antibody

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Phospho-RUNX2 (Ser340) Polyclonal Antibody

Product Details

PA5-105209

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RUNX2(Accession Q13950), corresponding to amino acid residues around phosphorylated S340.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816682

Product Specific Information

Antibody detects endogenous levels of RUNX2 only when phosphorylated at S340.

Target Information

RUNX2, a nuclear protein, is a member of the RUNX family of transcription factors and has an Runt DNA-binding domain. It is essential for membranous and endochondral bone formation. It not only regulates osteoblastic differentiation and skeletal morphogenesis but also acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer and with more affinity, as a subunit of a heterodimeric complex. It plays a critical role in increasing TGFBR1 expression by osteoblasts and functions in cooperation with DLX5 or a related factor to activate osteoblast-specific gene expression. Mutations lead to disorders in bone development like cleidocranial dysplasia (CCD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acute myeloid leukemia 3 protein; AKV core binding factor; AML-3; CBF-alpha-1; core binding factor alpha 1; Core-binding factor subunit alpha-1; core-binding factor, runt domain, alpha subunit 1; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2-alpha A; PEBP2 alpha A; PEBP2-alpha A; Polyomavirus enhancer-binding protein 2 alpha A subunit; runt domain, alpha subunit 1; runt related transcription factor 2; Runt-related transcription factor 2; RUNX 2; RUNX-2; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit

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Gene Aliases: AML3; Cbf; CBF-alpha-1; Cbfa-1; CBFA1; CCD; CCD1; CLCD; LS3; OSF-2; OSF2; PEA2aA; PEBP2A; Pebp2a1; PEBP2aA; Pebpa2a; RUNX2

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UniProt ID: (Human) Q13950, (Mouse) Q08775

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Entrez Gene ID: (Human) 860, (Rat) 367218, (Mouse) 12393

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding ATP binding protein domain specific binding chromatin DNA binding bHLH transcription factor binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor binding histone deacetylase binding transcription regulatory region DNA binding repressing transcription factor binding DNA-binding transcription factor immunoglobulin fold transcription factor Runt transcription factor gene-specific transcriptional regulator
Process(es)
skeletal system development ossification osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte differentiation chondrocyte development osteoblast development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transmembrane receptor protein serine/threonine kinase signaling pathway smoothened signaling pathway cell proliferation positive regulation of cell proliferation gene expression regulation of gene expression positive regulation of gene expression hemopoiesis cell differentiation neuron differentiation T cell differentiation regulation of ossification bone mineralization BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis ligamentous ossification regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth regulation of cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation embryonic cranial skeleton morphogenesis skeletal system morphogenesis stem cell differentiation epithelial cell proliferation positive regulation of epithelial cell proliferation SMAD protein signal transduction stem cell proliferation response to sodium phosphate positive regulation of stem cell proliferation transcription, DNA-templated transcription from RNA polymerase II promoter cellular response to fibroblast growth factor stimulus positive regulation of ossification cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
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