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Invitrogen

Phospho-Rb (Ser795) Polyclonal Antibody

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Phospho-Rb (Ser795) Polyclonal Antibody

Product Details

PA5-104757

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RB1(Accession P06400), corresponding to amino acid residues around phosphorylated Ser795.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816230

Product Specific Information

Antibody detects endogenous levels of Retinoblastoma only when phosphorylated at Serine 795.

Target Information

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cleaved Rb; delta RB-p70; DRb-p70; P105RB; Phospho-Retinoblastoma; pp105; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; Retinoblastoma 1 (including osteosarcoma); retinoblastoma gene; retinoblastoma protein; retinoblastoma suceptibility protein; retinoblastoma susceptibility protein; retinoblastoma suspectibility protein; retinoblastoma-associated protein; unnamed protein product

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Gene Aliases: OSRC; p105-Rb; p110-RB1; pp105; pp110; PPP1R130; pRb; RB; Rb-1

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UniProt ID: (Human) P06400, (Mouse) P13405, (Rat) P33568

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Entrez Gene ID: (Human) 5925, (Mouse) 19645, (Rat) 24708

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding transcription corepressor activity protein binding enzyme binding kinase binding ubiquitin protein ligase binding identical protein binding phosphoprotein binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding importin-alpha family protein binding disordered domain specific binding DNA-binding transcription factor binding
Process(es)
G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter regulation of cell growth tissue homeostasis chondrocyte differentiation aortic valve morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of protein kinase activity apoptotic process Ras protein signal transduction spermatogenesis regulation of mitotic cell cycle negative regulation of cell proliferation negative regulation of signal transduction negative regulation of gene expression cell differentiation neuron differentiation negative regulation of cell growth sister chromatid biorientation neuron projection development heterochromatin assembly developmental process cellular response to insulin stimulus maintenance of mitotic sister chromatid cohesion glial cell apoptotic process skeletal muscle cell differentiation neuron maturation enucleate erythrocyte differentiation regulation of lipid kinase activity myoblast differentiation positive regulation of macrophage differentiation negative regulation of cell cycle positive regulation of mitotic metaphase/anaphase transition negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter digestive tract development cell morphogenesis involved in neuron differentiation negative regulation of epithelial cell proliferation negative regulation of inflammatory response striated muscle cell differentiation chromosome organization cell division neuron apoptotic process regulation of cell cycle protein localization to chromosome, centromeric region cellular response to xenobiotic stimulus hepatocyte apoptotic process negative regulation of cold-induced thermogenesis positive regulation of extracellular matrix organization negative regulation of hepatocyte apoptotic process positive regulation of collagen fibril organization negative regulation of myofibroblast differentiation regulation of G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle negative regulation of apoptotic signaling pathway chromatin remodeling positive regulation of transcription regulatory region DNA binding
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