This antibody is predicted to react with bovine and porcine based on sequence homology.
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Capump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
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Protein Aliases: Cardiac phospholamban; CMD1P; CMH18; phospholamban; PLB; PLN
Gene Aliases: CMD1P; CMH18; PLB; Plm; PLN