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Fabgennix
Phospholipase A2 Polyclonal Antibody
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Product Details
PLAP2-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 30-80 on human Phospholipase A2-activating protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Phospholipase A2 catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Group IB phospholipase A2; MGC119834; MGC119835; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; phospholipase A2 group IB; phospholipase A2, group 1B; phospholipase A2, group IB (pancreas); PLA2-Ib; unnamed protein product
Gene Aliases: PLA2; PLA2A; PLA2G1B; PPLA2; sPLA2IB
UniProt ID: (Bovine) P00593, (Human) P04054, (Rat) P04055, (Mouse) Q9Z0Y2
Entrez Gene ID: (Bovine) 282457, (Human) 5319, (Rat) 29526, (Mouse) 18778
calcium ion binding
bile acid binding
calcium-dependent phospholipase A2 activity
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity
receptor binding
hydrolase activity
metal ion binding
phospholipase
innate immune response in mucosa
lipid catabolic process
antibacterial humoral response
phosphatidylcholine metabolic process
phosphatidylglycerol metabolic process
arachidonic acid secretion
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of glomerular visceral epithelial cell apoptotic process
activation of MAPK activity
neutrophil mediated immunity
fatty acid biosynthetic process
phosphatidic acid biosynthetic process
actin filament organization
signal transduction
positive regulation of calcium ion transport into cytosol
glucose transport
leukotriene biosynthetic process
neutrophil chemotaxis
activation of phospholipase A2 activity
interleukin-8 production
cellular response to insulin stimulus
intracellular signal transduction
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
multicellular organism lipid catabolic process
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of protein secretion
positive regulation of immune response
positive regulation of NF-kappaB transcription factor activity
phospholipid metabolic process
lipid metabolic process
phospholipid catabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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