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Bethyl Laboratories
Plakoglobin Polyclonal Antibody
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FIGURE: 1 / 3
Plakoglobin Antibody (A303-718A) in IHC (P)
Detection of human Plakoglobin by immunohistochemistry. Sample: FFPE section of human prostate hyperplasia. Antibody: Affinity purified rabbit anti-Plakoglobin (Product # A303-718A) (Lot 1) used at a dilution of 1:1,000 (1 µg/mL). Detection: DAB.
Product Details
A303-718A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 695 and 745 of Human Junction Plakoglobin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
JUP is a major cytoplasmic protein which is the only known constituent common to sub membranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; Desmoplakin-3; desmosomal protein 3; Junction plakoglobin; OTTHUMP00000164735
Gene Aliases: CTNNG; DP3; DPIII; JUP; PDGB; PG; PKGB
UniProt ID: (Human) P14923
Entrez Gene ID: (Human) 3728
transcription coactivator activity
structural molecule activity
protein binding
ligand-dependent nuclear receptor binding
protein phosphatase binding
protein homodimerization activity
alpha-catenin binding
cadherin binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
microtubule cortical anchor activity
positive regulation of cell-matrix adhesion
desmosome assembly
cell adhesion
cell migration
regulation of cell proliferation
positive regulation of protein import into nucleus
negative regulation of blood vessel endothelial cell migration
skin development
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
detection of mechanical stimulus
canonical Wnt signaling pathway
endothelial cell-cell adhesion
cellular response to indole-3-methanol
protein localization to plasma membrane
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
positive regulation of canonical Wnt signaling pathway
cell-cell adhesion
regulation of ventricular cardiac muscle cell action potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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