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Prealbumin/transthyretin Polyclonal Antibody

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Prealbumin/transthyretin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer using 11891-1-AP (Prealbumin/transthyretin antibody) at dilution of 1:100 (under 40x lens).

Prealbumin/transthyretin Antibody in Western Blot (WB) — Human blood tissue were subjected to SDS PAGE followed by western blot with 11891-1-AP (Prealbumin/transthyretin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

11891-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 4 publications 4 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication
Immunocytochemistry (ICC/IF)	-	View 1 publication 1 publication
Immunohistochemistry (IHC)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Prealbumin/transthyretin Fusion Protein Ag2499 (1-147 aa encoded by BC020791) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.13 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MASHRLLLL CLAGLVFVSE AGPTGTGESK CPLMVKVLDA VRGSPAINVA VHVFRKAADD TWEPFASGKT SESGELHGLT TEEEFVEGIY KVEIDTKSYW KALGISPFHE HAEVVFTAND SGPRRYTIAA LLSPYSYSTT AVVTNPKE (1-147 aa encoded by BC020791)

Target Information

Transthyretin (TTR), generally called prealbumin, is a plasma protein that plays an important role in physiology such as a transporter of hormone thyroxine and retinal-binding protein. After produced primarily in the liver, TTR is excreted into the plasma. TTR represents a disproportionate fraction (25%) of CSF protein, prompting the suggestion that it is either selectively transported across the blood-CSF barrier or synthesized de novo within the central nervous system. Transthyretin is a constituent found to the neuritic plaques, neurofibrillary tangles, and microangiopathic lesions of senile cerebral amyloid. It has been reported that more than 40 different mutations in the TTR gene associated with amyloid deposition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Destabilised human transthyretin shapes the morphology of calcium carbonate crystals.

Biochimica et biophysica acta. General subjects

Wieczorek E,Chitruń A,Ożyhar A

Fri Feb 01 00:00:00 EST 2019

Is Transthyretin a Regulator of Ubc9 SUMOylation?

PloS one

Wieczorek E,Kędracka-Krok S,Sołtys K,Jankowska U,Hołubowicz R,Seliga J,Ożyhar A

Wed Aug 02 00:00:00 EDT 2017

Up-Regulation of Antioxidant Proteins in the Plasma Proteome during Saturation Diving: Unique Coincidence under Hypobaric Hypoxia.

PloS one

Domoto H,Iwaya K,Ikomi F,Matsuo H,Tadano Y,Fujii S,Tachi K,Itoh Y,Sato M,Inoue K,Shinomiya N

Tue Jun 13 00:00:00 EDT 2017

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice.

Diabetes

Zemany L,Bhanot S,Peroni OD,Murray SF,Moraes-Vieira PM,Castoldi A,Manchem P,Guo S,Monia BP,Kahn BB

Fri May 01 00:00:00 EDT 2015

Distinct neural stem cell tropism, early immune activation, and choroid plexus pathology following coxsackievirus infection in the neonatal central nervous system.

Laboratory investigation; a journal of technical methods and pathology

Puccini JM,Ruller CM,Robinson SM,Knopp KA,Buchmeier MJ,Doran KS,Feuer R

Sat Feb 01 00:00:00 EST 2014

Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS.

Developmental cell

Lanctot AA,Peng CY,Pawlisz AS,Joksimovic M,Feng Y

Mon May 13 00:00:00 EDT 2013

Proteome analysis of human cerebrospinal fluid as a diagnostic biomarker in patients with meningioma.

Medical science monitor : international medical journal of experimental and clinical research

Kim JH,Lee SK,Yoo YC,Park NH,Park DB,Yoo JS,An HJ,Park YM,Cho KG

Thu Nov 01 00:00:00 EDT 2012

A pediatric intramedullary spinal cord tumor with unusual solid-cystic and papillary features: a case report.

Neuropathology : official journal of the Japanese Society of Neuropathology

Iwasaki T,Kato M,Horie Y,Kato S,Akatsuka K,Watanabe T,Kuwamoto S,Murakami I,Hayashi K

Thu Dec 01 00:00:00 EST 2011

Bioinformatics

Protein Aliases: Amyloidosis I; ATTR; carpal tunnel syndrome 1; epididymis luminal protein 111; pre-albumin; Prealbumin; prealbumin, amyloidosis type I; TBPA; thyroxine-binding prealbumin; Transthyretin

Gene Aliases: CTS; CTS1; HEL111; HsT2651; PALB; TBPA; TTR

UniProt ID: (Human) P02766

Entrez Gene ID: (Human) 7276

Molecular Function: hydrolase

Function(s)

retinoid metabolic process purine nucleobase metabolic process transport extracellular matrix organization retinol metabolic process cellular protein metabolic process

Process(es)

hormone activity protein binding identical protein binding protein heterodimerization activity thyroid hormone binding

Prealbumin/transthyretin Polyclonal Antibody

Product Details

11891-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Immunocytochemistry (ICC/IF)

Immunohistochemistry (IHC)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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