This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
By Western blot, MA1-187 detects Human Progranulin at ~85 kDa.
Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acrogranin; CLN11; Epithelin precursor; Epithelin-1; Epithelin-2; GEP; Glycoprotein of 88 Kda; GP88; Granulin; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin F; Granulin G; Granulin precursor; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; Granulin-epithelin; Paragranulin; PC Cell-derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin
Gene Aliases: CLN11; GEP; GP88; GRN; PCDGF; PEPI; PGRN
UniProt ID: (Human) P28799
Entrez Gene ID: (Human) 2896