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Prohibitin 2 Polyclonal Antibody

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Prohibitin 2 Polyclonal Antibody

Product Details

BS-10283R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Prohibitin 2, amino acids 281-299.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell receptor associated protein 37; B-cell associated protein; B-cell receptor associated protein 37; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; BAP-37; D-prohibitin; MGC117268; NB4 apoptosis/differentiation related protein; phb2; phb2 {ECO:0000250|UniProtKB:Q99623}; Prohibitin-2; Repressor of estrogen receptor activity; unnamed protein product

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Gene Aliases: AU044498; BAP; Bap-37; Bap37; Bcap27; BCAP37; hBAP; p22; PHB2; PNAS-141; REA

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UniProt ID: (Human) Q99623, (Mouse) O35129, (Rat) Q5XIH7

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Entrez Gene ID: (Human) 11331, (Mouse) 12034, (Rat) 114766

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Function(s)
protein binding estrogen receptor binding amide binding identical protein binding protein homodimerization activity sphingolipid binding protein heterodimerization activity chromatin binding protein C-terminus binding protein N-terminus binding molecular_function
Process(es)
mitophagy positive regulation of immunoglobulin production protein import into nucleus mitochondrion organization sister chromatid cohesion cell migration regulation of complement activation intracellular estrogen receptor signaling pathway negative regulation of intracellular estrogen receptor signaling pathway mammary gland epithelial cell proliferation negative regulation of mammary gland epithelial cell proliferation RIG-I signaling pathway B cell activation negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription, DNA-templated protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity mammary gland branching involved in thelarche mammary gland alveolus development regulation of branching involved in mammary gland duct morphogenesis positive regulation of ERK1 and ERK2 cascade antiviral innate immune response regulation of cardiolipin metabolic process positive regulation of NIK/NF-kappaB signaling regulation of cytochrome-c oxidase activity protein import into nucleus, translocation transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of exit from mitosis positive regulation of cell cycle G1/S phase transition biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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