PA1-4230 detects the Prostein protein in human samples.
PA1-4230 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~55 kDa protein representing Prostein in metastatic adenocarcinoma LNCaP.FGC cells.
PA1-4230 immunogen is a mixture of synthetic peptides corresponding to the N- and C-terminal residues I(36) T Y V P P L L L E V G V E E(50) and F(537) A T Q V V F D K S D L A K Y S A(553) of human Prostein.
Prostein is a novel prostate-specific protein expressed in normal and malignant prostate tissues. This protein appears to be a type IIIa plasma membrane protein with a cleavable signal peptide and 11 transmembrane-spanning regions. Prostein expression is androgen responsive since treatment of LNCaP cells with androgen up-regulates prostein message and protein expression levels. Thus, prostein is a prostate-specific marker whose detection and quantitation may be useful in diagnosing and monitoring prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: prostate cancer associated protein 2; prostate cancer associated protein 6; prostate cancer associated protein 8; prostate cancer-associated gene 2; prostate cancer-associated gene 6; prostate cancer-associated gene 8; Prostate cancer-associated protein 6; Prostein; Solute carrier family 45 member 3; solute carrier family 45, member 3
Gene Aliases: IPCA-2; IPCA-6; IPCA-8; IPCA6; PCANAP2; PCANAP6; PCANAP8; PRST; SLC45A3
UniProt ID: (Human) Q96JT2
Entrez Gene ID: (Human) 85414
Molecular Function: secondary carrier transporter