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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 236 of Human Protein C|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28321 targets Protein C in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28321 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 236 of Human Protein C.
The PROC gene encodes protein C (EC 126.96.36.199), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; prepro-protein C; PROC1; protein C (inactivator of coagulation factors Va and VIIIa); type I protein C; Vitamin K-dependent protein C
APC; PC; PROC; PROC1; THPH3; THPH4