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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 236 of Human Protein C|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28321 targets Protein C in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28321 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 236 of Human Protein C.
The PROC gene encodes protein C (EC 188.8.131.52), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PROC1, THPH3, THPH4, PC, APC
anticoagulant protein C, autoprothrombin IIA, blood coagulation factor XIV, vitamin K-dependent protein C, APC, PC, PROC1