Positive Control: 293T, A431, human plasma, mouse plasma, rat plasma
Predicted Reactivity: Rhesus Monkey (96%), Bovine (80%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Prothrombin (Coagulation factor II) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activation peptide fragment 1; Activation peptide fragment 2; coagulation factor 2; Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; PT; serine protease; thrombin; Thrombin heavy chain; Thrombin light chain
Gene Aliases: Cf-2; Cf2; F2; FII; PT; RPRGL2; THPH1