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Protor-1 Polyclonal Antibody
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Product Details
BS-3866R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Protor-1, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: proline rich 5 (renal); Proline-rich protein 5; Protein observed with Rictor-1; Protor-1; prr5; prr5 {ECO:0000250|UniProtKB:P85299}; Rho GTPase activating protein 8; RP1-181C9.3; unnamed protein product
Gene Aliases: Arhgap8; AU043908; C030017C09Rik; C78947; FLJ20185k; PP610; PROTOR-1; PROTOR1; PRR5
UniProt ID: (Human) P85299, (Rat) Q5FVG6, (Mouse) Q812A5
Entrez Gene ID: (Human) 55615, (Rat) 315189, (Mouse) 109270
cytoskeleton organization
positive regulation of cell growth
cellular response to nutrient levels
TORC2 signaling
negative regulation of apoptotic process
protein kinase B signaling
positive regulation of protein kinase B signaling
positive regulation of protein phosphorylation
positive regulation of phosphatidylinositol 3-kinase signaling
cell cycle
actin cytoskeleton organization
positive regulation of cell migration
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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