This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: GADVVDVAAD SMSGMTSQPS MGALVACTRG TPLDTEVPME RVFDYSEYWE GARGLYAAFD CTATMKSGNS DVYENEIPGG QYTNLHFQ
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.
Protein Aliases: EC 188.8.131.52; PCB; PYC; Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase
Gene Aliases: PC; PCB
UniProt ID: (Human) P11498
Entrez Gene ID: (Human) 5091