FIGURE: 1 / 3
Positive Control: 293T, A431, HeLa, HepG2
Predicted Reactivity: Pig (97%), Chicken (84%), Rhesus Monkey (100%), Bovine (96%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.
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Protein Aliases: EC 18.104.22.168; PCB; PYC; Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase
Gene Aliases: PC; PCB; Pcx