Invitrogen

QSOX1 Polyclonal Antibody

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Protocols

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QSOX1 Antibody in Western Blot (WB) — Western Blot analysis of QSOX1 in various cell lines using a QSOX1 Polyclonal antibody (Product # PA5-120881) at a dilution of 1:1,000. 25 µg of lysate or protein were loaded into each lane. A blocking buffer of 3% nonfat dry milk in TBST was used. An HRP conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a 1:10,000 dilution. Chemiluminescent detection was performed for 1s.

Product Details

PA5-120881

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500 - 1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:200	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human QSOX1 (NP_001004128.1). View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	2.671 mg/mL
Purification	Affinity Chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.05% ProClin 300
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2914453

Product Specific Information

Positive test controls include: NCI-H460, U-251MG, Mouse heart. The target is usually found in the following locations: Golgi apparatus membrane, Secreted, Single-pass membrane protein, extracellular space.

Target Information

The QSOX1 gene, also known as Quiescin Q6, is a fusion of two ancient genes: thioredoxin and ERV1. Its expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. The QSOX1 protein oxidizes sulfhydryl groups to form disulfide bonds in proteins. QSOX1 expression is induced by hypoxia and appears to protect cells against oxidative stress-induced apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hQSOX; mSOx; Quiescin Q6; quiescin Q6 sulfhydryl oxidase 1; RP11-502H18.3; Skin sulfhydryl oxidase; Sulfhydryl oxidase 1; testis tissue sperm-binding protein Li 62n; thiol oxidase 1

Gene Aliases: 1300003H02Rik; Q6; QSCN6; QSOX; QSOX1; SOx; UNQ2520/PRO6013

UniProt ID: (Human) O00391, (Mouse) Q8BND5

Entrez Gene ID: (Human) 5768, (Mouse) 104009

Molecular Function: oxidase