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Invitrogen
RAB23 Polyclonal Antibody
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Product Details
PA5-18877
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (PNKQRTKKNRNP) corresponding to the C-terminus amino acids of RAB23 (aa 219-226).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine, human and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781H0695; MGC8900; open brain 2; OTTHUMP00000040021; protein open brain; RAB 23; rab-15; ras-related protein Rab-23; RP3-496N17.3
Gene Aliases: AW545388; opb; opb2
Entrez Gene ID: (Mouse) 19335
autophagosome assembly
neural tube closure
transport
intracellular protein transport
cellular defense response
signal transduction
small GTPase mediated signal transduction
multicellular organism development
nervous system development
regulation of smoothened signaling pathway
protein transport
spinal cord dorsal/ventral patterning
dorsal/ventral neural tube patterning
Rab protein signal transduction
cilium assembly
embryonic digit morphogenesis
negative regulation of transcription factor import into nucleus
negative regulation of proteolysis
craniofacial suture morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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