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RAB3GAP1 Antibody (PA5-120651) in WB
Western blot analysis of RAB3GAP1 in extracts of various cell lines. Samples were incubated with RAB3GAP1 Polyclonal antibody (Product # PA5-120651) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
Product Details
PA5-120651
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 500-780 of human RAB3GAP1 (NP_001165906.1).
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914223
Product Specific Information
Positive test controls include: HeLa, HepG2, Jurkat, Mouse lung, Mouse brain, Rat brain.
Immunogen sequence: GLASGPPDLR CCLLHQKLQM LNCCIERKKA RDEGKKTSAS DVTNIYPGDA GKAGDQLVPD NLKETDKEKG EVGKSWDSWS DSEEEFFECL SDTEELKGNG QESGKKGGPK EMANLRPEGR LYQHGKLTLL HNGEPLYIPV TQEPAPMTED LLEEQSEVLA KLGTSAEGAH LRARMQSACL LSDMESFKAA NPGCSLEDFV RWYSPRDYIE EEVIDEKGNV VLKGELSARM KIPSNMWVEA WETAKPIPAR RQRRLFDDTR EAEKVLHYLA IQKPADLARH L
Target Information
RAB3GAP1, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rab 3 GAP p130; Rab3 GAP p130; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; Rab3-GAP; Rab3-GAP p130
Gene Aliases: 1700003B17Rik; 4732493F09Rik; AL117896; KIAA0066; P130; RAB3GAP; RAB3GAP1; RAB3GAP130; WARBM1
UniProt ID: (Human) Q15042, (Mouse) Q80UJ7
Entrez Gene ID: (Human) 22930, (Mouse) 226407
brain development
positive regulation of gene expression
hypothalamus development
lipid particle organization
camera-type eye development
regulation of GTPase activity
positive regulation of GTPase activity
regulation of short-term neuronal synaptic plasticity
excitatory postsynaptic potential
face morphogenesis
positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
establishment of protein localization to endoplasmic reticulum membrane
positive regulation of protein lipidation
regulation of calcium ion-dependent exocytosis of neurotransmitter
positive regulation of endoplasmic reticulum tubular network organization
positive regulation of autophagosome assembly
regulation of synaptic vesicle priming
synaptic vesicle transport
protein stabilization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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