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Proteintech
RAD50 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-29390
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RAD50 fusion protein Ag29949
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LDSRKKQME KDNSELEEKM EKVFQGTDEQ LNDLYHNHQR TVREKERKLV DCHRELEKLN KESRLLNQEK SELLVEQGRL QLQADRHQEH IRARDSLIQS LATQLELDGF ERGPFSERQI KNFHKLVRER QEGEAKTANQ LMNDFAEKET LK
Target Information
Rad50-13B3 recognizes human Rad50, a 153a protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, Rad50 and Mre11 redistribute and are co-localized within the nucleus of damaged cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein RAD50; hRAD50; hsRAD50; mRad50; RAD50 2; RAD50 homolog, double strand break repair protein; RAD50 PEN; RAD50-2; RAD50-3
Gene Aliases: hRad50; Mrell; NBSLD; RAD50; RAD502; Rad50l
UniProt ID: (Human) Q92878, (Rat) Q9JIL8
Entrez Gene ID: (Human) 10111, (Mouse) 19360, (Rat) 64012
single-stranded DNA endodeoxyribonuclease activity
DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
adenylate kinase activity
protein binding
ATP binding
3'-5' exonuclease activity
protein binding, bridging
single-stranded telomeric DNA binding
metal ion binding
G-quadruplex DNA binding
nucleotide binding
double-stranded DNA binding
hydrolase activity
ATPase activity
regulation of mitotic recombination
telomere maintenance
DNA repair
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
cell cycle
regulation of mitotic cell cycle
positive regulation of protein autophosphorylation
DNA duplex unwinding
positive regulation of kinase activity
negative regulation of viral entry into host cell
chromosome organization
protein heterooligomerization
meiotic cell cycle
chromosome organization involved in meiotic cell cycle
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
reciprocal meiotic recombination
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
double-strand break repair via nonhomologous end joining
viral process
telomeric 3' overhang formation
positive regulation of telomere maintenance
nucleotide phosphorylation
regulation of signal transduction by p53 class mediator
negative regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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