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Invitrogen
RAD51C Polyclonal Antibody
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FIGURE: 1 / 5
RAD51C Antibody (PA5-101975) in ICC/IF
Immunocytochemistry analysis of RAD51C in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with RAD51C polyclonal antibody (Product # PA5-101975) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-101975
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RAD51C(Accession O43502), corresponding to amino acid residues M165-D215.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Rad51C.
Target Information
ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein RAD51 homolog 3; member of the Rad51 family of related proteins; MGC104277; R51H3; RAD51 homolog C; RAD51-like protein 2; truncated form of Rad51C, a member of the Rad51 family of related proteins; unnamed protein product; yeast RAD51 homolog 3
Gene Aliases: BROVCA3; FANCO; R51H3; RAD51C; RAD51L2; RGD1563765
UniProt ID: (Human) O43502, (Mouse) Q924H5
Entrez Gene ID: (Human) 5889, (Mouse) 114714, (Rat) 497976
meiotic DNA recombinase assembly
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA repair
DNA recombination
cellular response to DNA damage stimulus
sister chromatid cohesion
female meiosis sister chromatid cohesion
reciprocal meiotic recombination
male meiosis I
spermatogenesis
positive regulation of G2/M transition of mitotic cell cycle
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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