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Invitrogen
RAE1 Polyclonal Antibody
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FIGURE: 1 / 1
RAE1 Antibody (PA5-93166) in WB
Western blot analysis of RAE1 in extracts of various cell lines. Samples were incubated with RAE1 Polyclonal antibody (Product # PA5-93166) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-93166
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLSSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE ELKPRNKK; Positive Samples: Mouse brain, Mouse spleen, Mouse thymus, Rat brain; Cellular Location: Cytoplasm, Nucleus
Target Information
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ30608; HGNC:9828; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer); MGC117333; MGC126076; MGC126077; migration-inducing gene 14; mRNA export factor; mRNA export factor RAE1; mRNA export protein; mRNA-associated protein MRNP 41; mRNA-binding protein, 41-kD; OTTHUMP00000166110; Rae1 protein homolog; RAE1 RNA export 1 homolog; RP4-800J21.2
Gene Aliases: 3230401I12Rik; MNRP; 41; D2Ertd342e; dJ481F12.3; dJ800J21.1; MIG14; MNRP41; MRNP41; RAE1
UniProt ID: (Human) P78406, (Rat) Q3SWS8, (Mouse) Q8C570
Entrez Gene ID: (Human) 8480, (Rat) 362281, (Mouse) 66679
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
mRNA export from nucleus
tRNA export from nucleus
protein import into nucleus
mitotic nuclear envelope disassembly
regulation of glucose transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
cellular response to organic cyclic compound
intracellular transport of virus
regulation of cellular response to heat
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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