|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to residues near the carboxy terminus of human RAGE isoform 1 protein|
|Storage buffer||0.01M HEPES, pH 7.5, with 100µg/ml BSA, 50% glycerol, 0.15M NaCl|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The receptor for advanced glycation end products (RAGE) is involved in eliciting oxidative stress that results in inflammatory and thrombogenic responses when activated by its ligand, advanced glycation end products (AGE). RAGE is encoded by the class III region of the major histocompatibility complex, which is expressed at sites of inflammation, particularly on inflammatory and epithelial cells. RAGE exists in either membrane bound or as a soluble form (sRAGE) lacking the transmembrane and intracytoplasmic domains. sRAGE also consists of alternate forms including endogenous secretory RAGE (esRAGE). These complexes can bind ligands like AGE and antagonize RAGE signalling.
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