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RALDH2 Polyclonal Antibody
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FIGURE: 1 / 3
RALDH2 Antibody (BS-3676R) in IHC (P)
Formalin-fixed and paraffin-embedded mouse embryo labeled with Anti-RALDH2 Polyclonal Antibody, Unconjugated(bs-3676R) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG,Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C.
Product Details
BS-3676R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RALDH2, amino acids 441-518.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AL1A2; alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase 1A2; Aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; ALDH1A2; neckless; nls; no-fin; nof; RALDH 2; RALDH(II); RALDH2; Retinal dehydrogenase 2; retinal dehydrogenase, type II; retinaldehyde dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2; unnamed protein product
Gene Aliases: ALDH1A2; Aldh1a7; AV116159; DIH4; fb50h01; RALDH(II); Raldh-2; Raldh1; RALDH2; RALDH2-T
UniProt ID: (Human) O94788, (Mouse) Q62148, (Rat) Q63639
Entrez Gene ID: (Human) 8854, (Mouse) 19378, (Rat) 116676, (Zebrafish) 116713
retinal dehydrogenase activity
3-chloroallyl aldehyde dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
retinal binding
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
blood vessel development
kidney development
liver development
retinoic acid biosynthetic process
heart morphogenesis
cellular aldehyde metabolic process
lipid metabolic process
vitamin A metabolic process
midgut development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
determination of bilateral symmetry
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of gene expression
neural crest cell development
morphogenesis of embryonic epithelium
neural tube development
pituitary gland development
neuron differentiation
lung development
embryonic limb morphogenesis
forebrain development
hindbrain development
pancreas development
embryonic camera-type eye development
response to estradiol
response to retinoic acid
response to vitamin A
response to cytokine
embryonic forelimb morphogenesis
ureter maturation
retinol metabolic process
retinoic acid metabolic process
retinal metabolic process
9-cis-retinoic acid biosynthetic process
camera-type eye development
positive regulation of apoptotic process
retinoic acid receptor signaling pathway
embryonic digestive tract development
cardiac muscle tissue development
protein homotetramerization
face development
cellular response to retinoic acid
regulation of vascular endothelial cell proliferation
retinoid metabolic process
regulation of endothelial cell proliferation
heart looping
heart development
metabolic process
oxidation-reduction process
somitogenesis
determination of left/right symmetry
hindbrain morphogenesis
central nervous system myelination
myelination in peripheral nervous system
fin regeneration
pectoral fin development
pronephric duct morphogenesis
axial mesoderm development
paraxial mesoderm development
regulation of retinoic acid receptor signaling pathway
digestive tract morphogenesis
camera-type eye morphogenesis
embryonic viscerocranium morphogenesis
pronephros development
face morphogenesis
pancreas field specification
glomerular visceral epithelial cell development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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