This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: 293T, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2.
Predicted reactivity: Mouse (96%), Rat (95%), Xenopus laevis (86%), Chicken (90%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.
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Protein Aliases: MGC20266; Ran GTPase-activating protein 1; RanGAP1; segregation distorter homolog; segregation distortion
Gene Aliases: C79654; Fug1; KIAA1835; mKIAA1835; RANGAP; RANGAP1; SD