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Invitrogen
RAP Polyclonal Antibody
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FIGURE: 1 / 1
RAP Antibody (PA5-97936) in WB
Western Blot analysis of RAP using a RAP Polyclonal antibody (Product # PA5-97936). Positive WB detected in: THP-1 whole cell lysate, A375 whole cell lysate. All lanes: LRPAP1 antibody at 1:2000. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 42 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-97936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Alpha-2-macroglobulin receptor-associated protein (35-357AA)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.87 mg/mL
Amount
287 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The term RAP typically refers to receptor-associated protein, encoded by the LRPAP1 gene, which plays a significant role in the trafficking and function of certain receptors within cells. RAP is primarily involved in the regulation of low-density lipoprotein receptor-related proteins (LRPs) by acting as a chaperone during protein transport within the endoplasmic reticulum (ER). It prevents premature ligand binding and assists in the proper folding and assembly of receptor complexes, ensuring efficient receptor function and trafficking to the cell surface. RAP also influences cellular processes related to cholesterol metabolism and cell signaling through its interactions with these receptors. Its function is crucial for transporting and recycling receptors involved in various pathways, including lipid metabolism, endocytosis, and cellular homeostasis. Dysregulation of RAP or related receptor functions can impact metabolic health and are implicated in conditions such as atherosclerosis, neurodegenerative disorders, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39 kDa receptor-associated protein; low density lipoprotein receptor-related protein associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); unnamed protein product
Gene Aliases: A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MYP23; RAP
UniProt ID: (Human) P30533
Entrez Gene ID: (Human) 4043
negative regulation of receptor internalization
signal transduction
negative regulation of very-low-density lipoprotein particle clearance
regulation of receptor-mediated endocytosis
amyloid-beta clearance by transcytosis
extracellular negative regulation of signal transduction
negative regulation of beta-amyloid clearance
positive regulation of beta-amyloid clearance
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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