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Invitrogen
RAP1 Polyclonal Antibody
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Product Details
PA5-75367
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 220-270 of Human RAP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length(1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dopamine receptor-interacting protein 5; RAP1 homolog; Repressor/activator protein 1 homolog; tel; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TERF21P; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric protein Rap1; TRF2-interacting telomeric RAP1 protein; unnamed protein product
Gene Aliases: DRIP5; MNCb-0448; MNCb-0628; PP8000; RAP1; TERF2IP
UniProt ID: (Human) Q9NYB0, (Rat) Q5EAN7, (Mouse) Q91VL8
Entrez Gene ID: (Human) 54386, (Rat) 307861, (Mouse) 57321
telomere maintenance
negative regulation of protein phosphorylation
regulation of transcription, DNA-templated
telomere maintenance via telomerase
regulation of double-strand break repair via homologous recombination
telomere maintenance via telomere lengthening
telomere capping
protection from non-homologous end joining at telomere
regulation of telomere maintenance
negative regulation of telomere maintenance
positive regulation of telomere maintenance
intracellular signal transduction
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of DNA recombination at telomere
positive regulation of NF-kappaB transcription factor activity
protein localization to chromosome, telomeric region
positive regulation of NIK/NF-kappaB signaling
transcription, DNA-templated
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein acetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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