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RAR alpha Polyclonal Antibody

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RAR alpha Polyclonal Antibody

Product Details

BS-0251R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OVA conjugated synthetic peptide derived from mouse Retinoic acid Receptor Alpha, amino acids 361-462.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: nuclear receptor; Nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; PML gene product; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR Alpha; RAR alpha 1; RAR-alpha; RARA; retinoic acid; retinoic acid receptor; Retinoic acid receptor alpha; retinoic acid receptor, alpha polypeptide; RRA; TTMV/RARA fusion; TTMV/RARA fusion protein; unnamed protein product

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Gene Aliases: NR1B1; RAR; RARA; RARalpha; RARalpha1

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UniProt ID: (Human) P10276, (Mouse) P11416

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Entrez Gene ID: (Human) 5914, (Rat) 24705, (Mouse) 19401

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Function(s)
translation repressor activity, nucleic acid binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription coactivator binding retinoic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding protein binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding sequence-specific DNA binding retinoic acid-responsive element binding metal ion binding mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding heterocyclic compound binding sequence-specific double-stranded DNA binding RNA polymerase II regulatory region DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity transcription corepressor activity transcription factor binding drug binding phosphatidylinositol 3-kinase regulator activity transcription regulatory region DNA binding protein heterodimerization activity regulatory region DNA binding C4 zinc finger nuclear receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development neural tube closure liver development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development regulation of transcription, DNA-templated protein phosphorylation germ cell development spermatogenesis female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation male gonad development positive regulation of gene expression negative regulation of gene expression negative regulation of translation hippocampus development cell differentiation prostate gland development regulation of granulocyte differentiation negative regulation of granulocyte differentiation embryonic camera-type eye development regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine multicellular organism growth mRNA transcription from RNA polymerase II promoter regulation of apoptotic process negative regulation of apoptotic process apoptotic cell clearance response to ethanol negative regulation of cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity retinoic acid receptor signaling pathway positive regulation of binding ventricular cardiac muscle cell differentiation Sertoli cell fate commitment limb development face development bone development trachea cartilage development chondroblast differentiation negative regulation of cartilage development cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus nucleus-associated proteasomal ubiquitin-dependent protein catabolic process regulation of hematopoietic progenitor cell differentiation negative regulation of pri-miRNA transcription from RNA polymerase II promoter transcription, DNA-templated transcription from RNA polymerase II promoter signal transduction positive regulation of phosphatidylinositol 3-kinase signaling intracellular estrogen receptor signaling pathway steroid hormone mediated signaling pathway regulation of phosphatidylinositol 3-kinase activity negative regulation of translational initiation positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade
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