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Invitrogen
RASD2 Polyclonal Antibody
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Product Details
PA5-20438
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the carboxy terminus of the human TEM2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human colon tissue lysate.
PA5-20438 can be used with blocking peptide PEP-0555.
Target Information
Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein Rhes; Ras homolog enriched in striatum; RASD family, member 2; SE6C; Tumor endothelial marker 2
Gene Aliases: 4930526B11Rik; AU045414; MGC:4834; RASD2; Rhes; TEM-2; TEM2
UniProt ID: (Human) Q96D21, (Rat) P63033, (Mouse) Q9WVD3
Entrez Gene ID: (Human) 23551, (Rat) 171099, (Mouse) 75141
synaptic transmission, dopaminergic
small GTPase mediated signal transduction
locomotory behavior
negative regulation of protein ubiquitination
positive regulation of protein sumoylation
regulation of cAMP-mediated signaling
positive regulation of protein kinase B signaling
signal transduction
behavior
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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