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Proteintech
RASIP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
17971-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RASIP1 Fusion Protein Ag11982 (617-963 aa encoded by BC028614)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IGDRQPENH PEGVPEVPLT PEAVSVELRP LMLWMANTTE LLSFVQEKVL EMEKEADQED PQLCNDLELC DEAMALLDEV IMCTFQQSVY YLTKTLYSTL PALLDSNPFT AGAELPGPGA ELGAMPPGLR PTLGVFQAAL ELTSQCELHP DLVSQTFGYL FFFSNASLLN SLMERGQGRP FYQWSRAVQI RTNLDLVLDW LQGAGLGDIA TEFFRKLSMA VNLLCVPRTS LLKASWSSLR TDHPTLTPAQ LHHLLSHYQL GPGRGPPAAW DPPPAEREAV DTGDIFESFS SHPPLILPLG SSRLRLTGPV TDDALHRELR RLRRLLWDLE QQELPANYRH GPPVATSP (617-963 aa encoded by BC028614)
Target Information
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: RAIN; unnamed protein product
Gene Aliases: 1110025D03Rik; 2610025P08Rik; RAIN
UniProt ID: (Human) Q5U651, (Mouse) Q3U0S6
Entrez Gene ID: (Human) 54922, (Mouse) 69903, (Rat) 292912
angiogenesis
vasculogenesis
signal transduction
positive regulation of cell proliferation
negative regulation of autophagy
positive regulation of integrin activation
negative regulation of Rho protein signal transduction
branching morphogenesis of an epithelial tube
negative regulation of membrane permeability
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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