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RASSF1 Polyclonal Antibody
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FIGURE: 1 / 4
RASSF1 Antibody (BS-1234R) in ICC/IF
Formalin-fixed and paraffin-embedded human oral squamous cell labeled with Anti-RASSF1A Polyclonal Antibody, Unconjugated(bs-1234R) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, FITC conjugated(bs-0295G-FTIC)used at 1:200 dilution for 40 minutes at 37°C.
Product Details
BS-1234R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RASSF1, amino acids 145-260.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 123F protein; cardiac-specific ras association domain family 1 protein; pancreas-specific ras association domain family 1 protein; Protein 123F2; putative RAS effector and tumor suppressor protein; Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family 1; Ras association domain-containing protein 1; rassf1; RASSF1A; RASSF1A tumor suppressor; RASSF1B; RASSF1C; RASSF1F; Ras association (RalGDS/AF-6) domain family 1; RASSF1G; Ras association (RalGDS/AF-6) domain family 1 protein; tumor suppressor protein RDA32; unnamed protein product; WUGSC:H_LUCA12.5
Gene Aliases: 123F2; AA536941; AU044980; NORE2A; RASSF1; RASSF1A; Rassf1B; Rassf1C; RDA32; REH3P21
UniProt ID: (Human) Q9NS23, (Mouse) Q99MK9
Entrez Gene ID: (Human) 11186, (Mouse) 56289, (Rat) 363140
cellular response to DNA damage stimulus
signal transduction
Ras protein signal transduction
positive regulation of protein ubiquitination
protein stabilization
regulation of cell cycle
regulation of cell cycle G1/S phase transition
cell cycle
cell cycle arrest
intracellular signal transduction
negative regulation of cell cycle arrest
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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