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RB1 Polyclonal Antibody, MaxPab™

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RB1 Polyclonal Antibody, MaxPab™

Product Details

H00005925-B01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RB1 (ABM85678.1, 1 a.a. approximately 928 a.a) full-length human protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

50 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MPPKTPRKTA ATAAAAAAEP PAPPPPPPPE EDPEQDSGPE DLPLVRLEFE ETEEPDFTAL CQKLKIPDHV RERAWLTWEK VSSVDGVLGG YIQKKKELWG ICIFIAAVDL DEMSFTFTEL QKNIEISVHK FFNLLKEIDT STKVDNAMSR LLKKYDVLFA LFSKLERTCE LIYLTQPSSS ISTEINSALV LKVSWITFLL AKGEVLQMED DLVISFQLML CVLDYFIKLS PPMLLKEPYK TAVIPINGSP RTPRRGQNRS ARIAKQLEND TRIIEVLCKE HECNIDEVKN VYFKNFIPFM NSLGLVTSNG LPEVENLSKR YEEIYLKNKD LDARLFLDHD KTLQTDSIDS FETQRTPRKS NLDEEVNVIP PHTPVRTVMN TIQQLMMILN SASDQPSENL ISYFNNCTVN PKESILKRVK DIGYIFKEKF AKAVGQGCVE IGSQRYKLGV RLYYRVMESM LKSEEERLSI QNFSKLLNDN IFHMSLLACA LEVVMATYSR STSQNLDSGT DLSFPWILNV LNLKAFDFYK VIESFIKAEG NLTREMIKHL ERCEHRIMES LAWLSDSPLF DLIKQSKDRE GPTDHLESAC PLNLPLQNNH TAADMYLSPV RSPKKKGSTT RVNSTANAET QATSAFQTQK PLKSTSLSLF YKKVYRLAYL RLNTLCERLL SEHPELEHII WTLFQHTLQN EYELMRDRHL DQIMMCSMYG ICKVKNIDLK FKIIVTAYKD LPHAVQETFK RVLIKEEEYD SIIVFYNSVF MQRLKTNILQ YASTRPPTLS PIPHIPRSPY KFPSSPLRIP GGNIYISPLK SPYKISEGLP TPTKMTPRSR ILVSIGESFG TSEKFQKINQ MVCNSDRVLK RSAEGSNPPK PLKKLRFDIE GSDEADGSKH LPGESKFQQK LAEMTSTRTR MQKQKMNDSM DTSNKEEK

Target Information

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cleaved Rb; delta RB-p70; DRb-p70; p105-Rb; P105RB; p110-RB1; Phospho-Retinoblastoma; pp110; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; Rb; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma gene; retinoblastoma suceptibility protein; retinoblastoma susceptibility protein; retinoblastoma suspectibility protein; Retinoblastoma-associated protein; unnamed protein product

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Gene Aliases: OSRC; p105-Rb; p110-RB1; pp110; PPP1R130; pRb; RB; RB1

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UniProt ID: (Human) P06400

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Entrez Gene ID: (Human) 5925

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription corepressor activity protein binding enzyme binding kinase binding ubiquitin protein ligase binding identical protein binding phosphoprotein binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding importin-alpha family protein binding disordered domain specific binding DNA-binding transcription factor binding
Process(es)
G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter regulation of cell growth tissue homeostasis chondrocyte differentiation aortic valve morphogenesis chromatin organization chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter negative regulation of protein kinase activity apoptotic process smoothened signaling pathway Ras protein signal transduction spermatogenesis regulation of mitotic cell cycle cell proliferation negative regulation of cell proliferation negative regulation of gene expression glial cell proliferation cell differentiation neuron differentiation negative regulation of cell growth sister chromatid biorientation neuron projection development heterochromatin assembly developmental process cellular response to insulin stimulus maintenance of mitotic sister chromatid cohesion glial cell apoptotic process skeletal muscle cell differentiation neuron maturation enucleate erythrocyte differentiation regulation of lipid kinase activity myoblast differentiation positive regulation of macrophage differentiation negative regulation of cell cycle positive regulation of mitotic metaphase/anaphase transition negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter digestive tract development cell morphogenesis involved in neuron differentiation epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response striated muscle cell differentiation chromosome organization cell division neuron apoptotic process regulation of cell cycle negative regulation of glial cell proliferation protein localization to chromosome, centromeric region cellular response to xenobiotic stimulus regulation of centromere complex assembly hepatocyte apoptotic process negative regulation of cold-induced thermogenesis positive regulation of extracellular matrix organization negative regulation of hepatocyte apoptotic process positive regulation of collagen fibril organization negative regulation of myofibroblast differentiation regulation of G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle positive regulation of transcription regulatory region DNA binding negative regulation of apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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